何梦 副教授

研究方向为神经退行性疾病的药物研发及机制研究，肥胖，糖尿病等代谢性疾病的药物研发及机制研究，抗精神病药物所致肥胖及相关代谢综合征的机制研究及控制。主持国家自然科学基金、湖北省自然科学基金和企业横向项目等共5项，参与多项国家及省部级科研项目，以一作或通讯作者发表论文16篇。主持教研项目1项，指导大学生自主创新项目2项，发表教研论文2篇，所授课程《药理学实验》获批武汉理工大学首批校级思政示范课程，《药理学》为思政课程建设项目。获2021年武汉理工大学教学成果奖（一等奖，排名6），第十一届武汉理工大学青年教师教学竞赛二等奖，参编教材《制药工程实验》。

研究领域

1.神经退行性疾病的药物研发及机制研究，

2.肥胖，糖尿病等代谢性疾病的药物研发及机制研究，

3.抗精神病药物所致肥胖及相关代谢综合征的机制研究及控制

教育及工作经历

1.武汉理工大学化学化工与生命科学学院制药工程系副教授（2016.07-至今）

2.澳大利亚伍伦贡大学药理学获博士学位（2010.09-2016.07）

3.西南大学微生物与生化药学硕士肄业（提前攻博）（2009.09-2010.09）

4.西南大学制药工程获学士学位（2005.09-2009.06）

代表性论文

1.Meng He, Jun Fan, Ruqin Zhou, Guanbin Gao, Ruoxi Li, YuFeng Zuo, Benben Li, Yanmei Li, Taolei Sun*. NLRP3/Caspase-1-Mediated Pyroptosis of Astrocytes Induced by Antipsychotics Is Inhibited by a Histamine H1 Receptor-Selective Agonist. Frontiers in aging neuroscience, 2022 May 9;14:847561

2.Jinqi Hu; Guanbin Gao *; Meng He ^#*; Qiang Yin; Xiaobing Gao; Haixing Xu, Taolei Sun *; Optimal route of gold nanoclusters administration in mice targeting Parkinson’s disease, Nanomedicine, 2020, 15(6):563-580.

3.Guanbin Gao^#; Rui Chen ^#; Meng He ^#; Jing Li ^#; Jing Li; Liyun Wang; Taolei Sun *; Gold nanoclusters for Parkinson's disease treatment, Biomaterials, 2019, 194: 36-46.

4.WenTing Li, XuFeng Huang, Chao Deng, Bao-Hua Zhang, Kun Qian, Meng He*, Taolei Sun**. Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex. Current Medical Science, 2021, 41(4):15.

5.Meng He; XuFeng Huang, Guanbin Gao, Ting Zhou; Wenting Li, Jinqi Hu, Jia Chen; Jing Li**; Sun Taolei*; Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate, Psychoneuroendocrinology，2019,104:286-299.

6.Meng He; Kun Qian; Ying Zhang; Xu-Feng Huang; Chao Deng; Baohua Zhang, Guanbin Gao, Jing Li; Hao Xie**; Taolei Sun*; Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain., Frontiers in Neuroscience, 2020, 14: 0-589650.

7.Meng He; Qingsheng Zhang; Chao Deng; Tiantian Jin; Xueqin Song; Hongqin Wang; XuFeng Huang*; Time-dependent effects of olanzapine treatment on the expression of histidine decarboxylase, H1 and H3 receptor in the rat brain: The roles in olanzapine-induced obesity, Psychoneuroendocrinology，2017, 85:190-199.

8.Meng He, Qingsheng Zhang, Chao Deng, Hongqin Wang, Xu-Feng Huang*, Olanzapine-activated AMP-activated protein kinase signaling in the dorsal vagal complex is attenuated by histamine H1 receptor agonist in female rats, Endocrinology, 2014, 155 (12):4895-4904.

9.Meng He, Qingsheng Zhang, Chao Deng, Hongqin Wang, Jiamei Lian, Xu-Feng Huang*, Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats, Psychoneuroendocrinology, 2014, 42, 153-164. 

10.Meng He, Chao Deng, Xu-Feng Huang*, The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain, CNS Drugs, 2013, 27 (6), 423-434.

联系方式

邮箱地址：menghe@whut.edu.cn