余瑶

余瑶 博士

研究领域

1.纳米药物载体

2.抗肿瘤策略及药物研发

3.生物医学探针制备及应用

4.生物医学分析策略及材料研发

科研项目

1. 山东省自然科学基金青年项目,基于二甲双胍-纳米金-MOFs 的肿瘤靶向治疗体系的构建、应用与机制研究, 10万元,2023.01.01-2025.12.30,ZR2022QE133,主持,在研。

2. 中央高校自主创新基金/武汉理工大学自主创新项目,诊疗一体化纳米金探针的构建、性质及体内外成像,5万元,20200101-20211031,3120620149,主持,结题。

3. 中央高校自主创新基金/武汉大学自主科研项目,IRF2在肥胖中的作用与机制研究,6万元,201901-202012,2042019kf0068,主持,结题。

4. 国家自然科学基金重点项目,基于响应性高分子动态氢键网络的糖蛋白组学富集分离新材料(项目负责人:孙涛垒,分解经费20万元),20151j0184,参与,结题。

5. 企业委托,Sa-1和Sa-2药物疾病模型横向委托开发合同(项目负责人:高冠斌),分解经费10万元),20192h0118,参与,在研。

6. 企业委托,Sa系列药物在阿兹海默病及糖尿病药效药理研究委托开发合同(项目负责人:何梦),分解经费30万元),20192h0331,参与,在研。

教育及工作经历

1.武汉理工大学化学化工与生命科学学院制药工程系讲师(2019.06-至今)

2.武汉大学人民医院助理研究员(2018.04-2019.06)

3.西安交通大学生物医学工程博士(2013.09-2018.03)

4.Johns Hopkins University生物医学工程联合培养博士(2016.09-2017.09)

5.台湾义守大学生物科技交换生(2010.09--2011.01)

6.西安交通大学生物医学工程学士(2009.09--2013.07)

代表性论文

1.Yang, Ting; Wang, Haiping; Zhou, Qikai; Huang, Wan; Zhang, Jun; Yu, Yao; (*)and Sun, Taolei*. A mild chemo-photothermal synergistic therapy for tumor based on gold-nanopaticles coupled with metformin, ACS applied nano materials. 2023, 6, 7, 5729–5736.

2.Huang, Wan; Zhang, Jun;Li Luo; Yu, Yao; (*) and Sun Taolei*. Nitric oxide and tumors: from small molecule donor to combination therapy. ACS Biomaterials Science & Engineering, 2023.1.9 2023, 9, 1, 139–152. IF 5.395

3.Zhang, Jun; Yang, Ting; Huang, Wan; Yu, Yao (*); Sun Taolei*. Applications of Gold Nanoparticles in Brain Diseases across the Blood-Brain Barrier. Current Medicinal Chemistry, 2022.05, 29, 10.2174/0929867329666220527121943. IF 4.53

4.Yang, Ting; Zhang, Jun; Yu, Yao (*) ; Sun, Taolei (*), Preparation, pharmacokinetic and application of gold nanoclusters (AuNCs) in tumor treatment, Current Medicinal Chemistry, 2021.03, 28(34):6690-7005. IF 4.53

5.Yu, Yao; Yang, Ting; Sun, Taolei (*), New insights into the synthesis, toxicity and applications of gold nanoparticles in CT imaging and treatment of cancer. Nanomedicine, 2020.5.20, 15(11):1127-1145. IF 5.3

6.Yu, Yao; Cai, Jingjing; She, Zhigang; Li, Hongliang (*), Insights into the Epidemiology, Pathogenesis, and Therapeutics of Nonalcoholic Fatty Liver Diseases, Advanced Science, 2019.2.20, 6(4): 1801585. IF: 15.84

7.Yu, Yao; Wu, Youshen; Liu, Jiajun; Liu, Yiming; Wu, Daocheng (*), Highly efficient dual-modal phosphorescence/computed tomography bioprobes based on an iridium complex and AuNP polyiohexol composite nanoparticles., Nanoscale, 2017.7.13, 9(27): 9447~9456. IF: 6.895

8. Yu, Yao; Wu, Youshen; Liu, Jiajun; Li, Ke; Wu, Daocheng (*), Metabolizable dopamine-coated gold nanoparticle aggregates: preparation, characteristics, computed tomography imaging, acute toxicity, and metabolism in vivo, Journal of Materials Chemistry B, 2016, 4(6): 1090~1099. IF: 5.344

9. Yu, Yao; Wu, Youshen; Liu, Jiajun; Zhan, Yonghua; Wu, Daocheng (*), Ultrasmall dopamine-coated nanogolds: preparation, characteristics, and CT imaging, Journal of Experimental Nanoscience, 2016, 11: 1~11. IF: 2.169

10.Chen, Z; Yu, Yao; Cai, Jingjing; Li, Hongliang (*), Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease, Trends in Endocrinology & Metabolism, 2019, https://doi.org/10.1016/j.tem.2019.08.006. IF: 11.641

11.Liu, Jiajun; Wu, Youshen; Yu, Yao; Li, Ke; Ji, Yuanyuan; Wu, Daocheng (*), Quantitative ratiometric phosphorescence hypoxia-sensing nanoprobes based on quantum dots/Ir(III) glycerol monoolein cubic-phase nanoparticles, Biosensors& Bioelectronics, 20171215, 98: 119-125. IF: 10.257

联系方式

邮箱地址:yyu@whut.edu.cn;yuyao1021@163.com