高冠斌 教授/博导
国家级高层次青年人才
湖北省青年拔尖人才
高冠斌，教授/博导，国家级高层次青年人才，湖北省青年拔尖人才，武汉理工大学材料复合新技术国家重点实验室研究员、神经退行性疾病纳米医药湖北省重点实验室副主任。主要研究方向是纳米生物医药材料，近五年主持科研项目12项，包括国家科技人才专项青年项目1项，国家自然科学基金项目3项(面上2+青年1)，湖北省青年拔尖人才项目1项，湖北省自然科学基金项目2项（面上1+青年1）；以第一/通讯作者在Natl. Sci. Rev.、Angew. Chem. Int. Ed.、Nano Lett. 、Biomaterials、Small等国际顶级期刊上发表SCI论文43篇；授权中国发明专利7件。入选国家“高层次人才特殊支持计划”青年拔尖人才（2024年）、湖北省楚天英才计划·青年拔尖人才（2023年）、中国科协优秀中外青年交流计划（2019年），兼任湖北省药品注册审评专家、湖北省医疗器械注册审评专家。
一、基本情况
出生年月：1987-01 籍贯：湖北随州
最高学历：武汉理工大学 工学博士；
工作单位：武汉理工大学
材料复合新技术国家重点实验室
神经退行性疾病纳米医药湖北省重点实验室
联系地址：武汉市洪山区珞狮路 122 号武汉理工大学西院新材所320-2
联系方式：gbgao@whut.edu.cn
二、教育经历
2010/09–2016/06，武汉理工大学，材料物理与化学，博士，导师：孙涛垒
2006/09–2010/06，武汉纺织大学，高分子材料与工程， 工学学士
三、工作经历
2023/01-至今 神经退行性疾病纳米医药湖北省重点实验室 副主任
2022/09-至今 武汉理工大学材料复合新技术国家重点实验室 教授、博士生导师
2018/09-2022/09 武汉理工大学材料复合新技术国家重点实验室 副教授、博士生导师
2016/07-2018/09 武汉理工大学材料复合新技术国家重点实验室 助理研究员、硕导
四、研究领域
1. 手性纳米材料的生物医学新效应、新应用；
2. 多尺度手性纳米生物界面材料调控多肽/蛋白构象；
3. 手性纳米生物医药材料在阿尔兹海默病(AD)和帕金森病(PD)诊疗中的应用；
4. 仿生纳米抑菌材料。
五、科研项目
1. 国家高层次人才特殊支持计划青年项目，2025/01-2027/12，210万，在研，主持
2. 国家自然科学基金面上项目，52273110，精确构筑纳微仿生界面用于精准调控淀粉样蛋白折叠与纤维化，2023/01/01-2026/12/31，53万元，在研，主持
3. 国家自然科学基金面上项目，21975191，智能响应性手性纳米生物界面材料调控多肽/蛋白质构象，2020/01/01-2023/12/31，65万元，在研，主持
4. 国家自然科学基金青年科学基金项目，21805218，多尺度微纳米手性界面Aβ聚集及纤维化调控机制研究，2019/01/01-2021/12/31，26万元，已结题，主持
5. 湖北省楚天英才计划·青年拔尖人才项目，202401jc0004，2023.11-2026.11，60万元，在研，主持
6. 湖北省自然科学基金面上项目，2021CFB299，用于蛋白构象病诊疗的纳米手性生物界面材料，2021/10/01-202309/30，8万元，在研，主持
7. 湖北省自然科学基金青年项目，2018CFB348，纳米手性界面调控Aβ聚集及纤维化，2018/03/19-2019/12/31，3万元，已结题（结题优秀），主持
8. 中国科协优秀中外青年交流计划，20191kx032，中国科协优秀中外青年交流计划（2019年度）02，2020/07-2021/12，5万元，在研，主持
9. 武汉市知识创新专项（曙光计划），20221j0044，手性纳米伴侣的设计制备及其调控淀粉样蛋白构象性能研究，2022/06-2024/06, 10万元，在研，主持
10. 横向科技项目（20192h0118），SA1和SA2药物疾病模型横向委托开发，2019/06/01-2024/05/31，300万元，在研，主持
11. 横向科技项目（20211h0421a），纳米生物界材料用于蛋白构象病诊疗基础研究，2021/07/01-2026/06/30，200万元，在研，主持
12.横向科技项目(20181h0232)，SA药物疾病模型横向委托开发, 2018/06-2021/12，100万元，在研，主持
六、代表性论文（*通讯作者）
1.Yuzhou Deng#, Guanbin Gao#,*, Liangchong Yu, Zijun Zhang, Bin Zhang, Hu Li, Xinyu Zhang, Lei Shen, Taolei Sun*, Engineering Core/Ligands Interfacial Anchors of Nanoparticles for Efficiently Inhibiting Both Aβ and Amylin Fibrillization, Small 2024, 20, 2312046.
2.Zijun Zhang#, Limei Qian#, Nan Zhang#, Xinyue Wang, Yunshen Fu, Guanbin Gao*, Taolei Sun*, Advances in Spiky Antibacterial Materials: From Bioinspired Design to Application, Small Structures 2024, Doi:10.1002/sstr.202400370.
3.Shuai Gong, Guanbin Gao*, Taolei Sun*, Lei Shen*, Inhibition of a-Synuclein Misfolding into β-Sheet Domains on Medium-Sized Gold Nanoclusters: Evidence from Enhanced Sampling MD Simulations, ACS Macro Letters 2024, 13, Doi:10.1021/acsmacrolett.4c00537.
4.Hu Li#, Guanbin Gao#,*, Liangchong Yu, Zijun Zhang, Bin Zhang, Yuzhou Deng, Qingxue Mu, Lei Shen*, Taolei Sun*, Interfacial metal atoms of metallic nano-chaperones on modulating amyloid fibrillation, Science China Materials 2024, 67(7), 2345-2354.
5.Furong Li#, Ye Yuan#, Donghao Lyu, Yujie Yi, Jingli Zhang*, Taolei Sun, Guanbin Gao*, Palladium-Catalyzed Domino Heck/Cross-Coupling Cyclization Reaction: Diastereoselective Synthesis of Furan-Containing Indolines, Journal of Organic Chemistry 2024, 89, 11, 7552-7560.
6.Linlin Yuan#, Zhenhua Gu#, Jingli Zhang#, Zijun Zhang, Quan Wan, Liangchong Yu, Qingxue Mu, Taolei Sun, Guanbin Gao*, A pentametallic high-entropy mixed-dimensional mesoporous heterostructure for azo-dye wastewater degradation and decolorization, Separation and Purification Technology 2024, 350,127951.
7.Zehui Yao, Zijun Zhang, Jingli Zhang, Jing Li, Guanbin Gao*, Taolei Sun*, Charge Effect of Mercaptobenzimidazole-Modified Ultrasmall Gold-Nanoparticles against Drug-Resistant Bacteria, ACS Applied Bio Materials, 2024, 7, 3330−3336.
8.Zhenhua Gu, Jingli Zhang, Zijun Zhang, Qingxue Mu, Liangchong Yu, Taolei Sun*, Lei Shen*, Guanbin Gao*, Interfacial charge effects of supported-metal-clusters heterostructure on azo hydrogenation catalyzation, Nano Research 2024,17(5),3853-3862.
9.Jingli Zhang, Weipeng Xu, Du Wang, Ye Yuan, Yongqi Bai, Minyan Wang*, Guanbin Gao*, Taolei Sun*, Divergent reactivity of Acrylamides and β-Chloroenones under Base-Controlled Palladium Catalysis: Construction of Spirooxindoles and Furan-containing 3,3-Disubstituted Oxindoles, Organic Chemistry Frontiers, 2024, 11(2), 348-357.
11. Lin Zhou, Guanbin Gao*, Zhongjie Ma, Zijun Zhang, Zhenhua Gu, Liangchong Yu, Xiaohan Li, Nan Zhang, Limei Qian, Zelin Tao and Taolei Sun*, Gold Nanoclusters Enhance the Efficacy of the Polymer-Based Chaperone in Restoring and Maintaining the Native Conformation of Human Islet Amyloid Polypeptide, ACS Applied Materials & Interfaces, 2023, 15(2),3409-3419.
12. Wenrui Chen# , Boran Li# , Guanbin Gao*, Taolei Sun*, Chiral supramolecular nanomaterials: From chirality transfer and amplification to regulation and applications, Interdisciplinary Materials 2023, 2, 689-713.
13. Hao Deng, Zhenhua Gu, Wenshan Zheng, Taolei Sun, Guanbin Gao*, Engineering Dumbbell-Shaped Au Nanobipyramid/Ag-CeO2 Plasmonic Bimetal-Semiconductor Heterostructures for Nitroaromatic Reduction. ACS Applied Nano Materials, 2023, 6(13), 11581-11589.
14. Baisheng Cao, Guanbin Gao*, Jingli Zhang, Zijun Zhang, Taolei Sun*, A smartphone-assisted colorimetric sensor based on Fe1-xS nanozyme for detection of glucose and ascorbic-acid in soft drinks. Microchemical Journal, 2023, 193, 109018.
15. Chengye Chen, Yilu Zeng, Guanbin Gao*, Taolei Sun*, and Lei Shen*, Flexibility Analysis of DNA Nanotubes with Prescribed Circumferences and Their Pearl-Necklace Assemblies with Gold Nanoclusters. Langmuir, 2023, 39, 9850-9856.
16. 郑文山, 高冠斌*, 邓浩, 孙涛垒*. Ag2Se@Ag2S 核壳量子点的室温合成及其近红外荧光性能优化[J], 化学学报, 2023, 81(7), 763-770.
17. Guanbin Gao*, Xinglin Liu, Zhenhua Gu, Qingxue Mu, Guowei Zhu, Ting Zhang, Cheng Zhang, Lin Zhou, Lei Shen* and Taolei Sun*, Engineering Nanointerfaces of Au25-Clusters for Chaperone-Mediated Peptide Amyloidosis, Nano Letters 2022, 22, 2964-2970.
18. Guanbin Gao*, Guowei Zhu, Liangchong Yu, Zijun Zhang, Ting Zhang, Xinglin Liu, Cheng Zhang, Lin Zhou and Taolei Sun*, Chiral effect on Aβ fibrillation from molecular-scale to nanoscale, Nano Research 2022, 15(7), 6721-6729.
19. Guanbin Gao*, Ting Zhang, Wenkang Zhang, Zhuoying Luo, Zijun Zhang, Zhenhua Gu, Liangchong Yu, Qinxue Mu and Taolei Sun*, High Efficiency and Related Mechanism of Au(RC) Nanoclusters on Disaggregating Aβ fibrils, J. Colloid Interf. Sci., 2022, 621, 67-76.
20. Cheng Zhang# , Xiaobing Gao# , Wenrui Chen# , Meng He, Yao Yu, Guanbin Gao*, Taolei Sun*, Advances of Gold Nanoclusters for Bioimaging, iScience, 2022, 25, 105022.
21. Meng He# , Jing Yao# , Zijun Zhang# , Ying Zhang, Rui Chen, Zhenhua Gu, XuFeng Huang, Chao Deng, Ruqin Zhou, Jun Fan, Baohua Zhang, Yanqian Xie, Guanbin Gao* and Taolei Sun*, Gold nanoclusters eliminate obesity induced by antipsychotics, Scientific Reports, 2022, 12, 5502.
22. Jun Fan, Ruqin Zhou, Meng He*, Ruoxi Li, Yufeng Zuo, Benben Li, Guanbin Gao* and Taolei Sun*, The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review. Frontiers in Neuroscience, 2022, 16, 947295.
23. Jianhang Li, Guanbin Gao*, Xintong Tang, Meng Yu, Meng He and Taolei Sun*, Isomeric Effect of Nano-Inhibitors on Aβ40 Fibrillation at The Nano-Bio Interface, ACS Applied Materials & Interfaces, 2021, 13, 4, 4894-4904.
24. 余梦, 张子俊, 朱国委, 谷振华, 段玉霖, 余良翀, 高冠斌*, 孙涛垒*. Ag2S 基近红外 II 区荧光量子点的水相合成优化探究[J], 化学学报, 2021, 79(10): 1281-1285.
25. Wenkang Zhang, Guanbin Gao*, Zhongjie Ma, Zhuoying Luo, Meng He and Taolei Sun*, Au23(CR)14 Nanocluster Restores Fibril Aβ’s Unfolded State with Abolished Cytotoxicity and Dissolves Endogenous Aβ Plaques, Natl. Sci. Rev., 2020, 7(4), 763-774.
26. Xintong Tang, Guanbin Gao*, Ting Zhang, Jianhang Li, Meng Yu, Meng He and Taolei Sun*, Charge Effects at Nano-Bio interfaces: A Model of Charged Gold Nanoclusters on Amylin Fibrillation, Nanoscale, 2020, 12, 18834-18843.
27. Zhuoying Luo, Guanbin Gao*, Zhongjie Ma, Qian Liu, Xiaobing Gao, Xintong Tang, Zhenxing Gao, Chaoyang Li* and Taolei Sun*, Cichoric Acid from Witloof Inhibit Misfolding Aggregation and Fibrillation of hIAPP, Int. J. Biol. Macromol., 2020, 148, 1272-1279.
28. Wenkang Zhang, Meng Yu, Wenbo Zhu, Liang Wang, Juncheng Wang, Feifei Yang, Jing Li, Guanbin Gao*, Temperature-Controlled β-Crystal-to-α-Crystal Phase Transition of HgS Nanoparticles, J. Nanosci. Nanotech., 2020, 20(4), 2567-2572;
29. Jinqi Hu, Guanbin Gao*, Meng He*, Qiang Yin, Xiaobing Gao, Haixing Xu, and Taolei Sun*, The Optimal Route of Gold Nanoclusters Administration in Mice Targeting Parkinson’s Disease, Nanomedicine, 2020, 15(6), 563-580.
30. 王君诚, 杨菲菲, 高冠斌*, 孙涛垒*, Ag 掺杂 HgS 量子点: 一种 pH 调谐的近红外Ⅱ区荧光纳米探针, 无机材料学报, 2019, 34(11), 1156-1160.
31. Zhongjie Ma, Guanbin Gao*, Zhuoying Luo, Xintong Tang and Taolei Sun*, Tuning Chirality Transfer and Amplification of Supraparticles via Solvent Inducing Self-aggregation of Chiral Gold Nanoclusters, J. Phys. Chem. C, 2019, 123, 24973-24978.
32. Jing Li, Rui Chen, Shasha Zhang, Zhongjie Ma, Zhuoying Luo, Guanbin Gao*, Chiral Effect at Nano-Bio Interface: A Model of Chiral Gold Nanoparticle on Amylin Fibrillation, Nanomaterials, 2019, 9(3), 412.
33. Juncheng Wang, Guanbin Gao*, Feifei Yang, Rui Chen, Liang Wang, Wenbo Zhu, Zhongjie Ma, Zhuoying Luo and Taolei Sun*, A Fluorescent Nanoprobe Based on HgS/ZnS Core/Shell Quantum Dots for In-Situ Rapid Visual Detection of Cr3+ , J. Nanopart. Res., 2019, 21(3), 50.
34. Feifei Yang, Guanbin Gao*, Juncheng Wang, Rui Chen, Wenbo Zhu, Liang Wang, Zhongjie Ma, Zhuoying Luo and Taolei Sun*, Chiral β-HgS Quantum Dots: Aqueous Synthesis, Optical Properties and Cytocompatibility, J. Colloid Interf. Sci., 2019, 537, 422-430.
35. Guanbin Gao, Rui Chen, Meng He, Jing Li, Jing Li, Liyun Wang and Taolei Sun*. Gold Nanoclusters for Parkinson’s Disease Treatment, Biomaterials, 2019, 194, 36-46.
36. Shan Wu, Guanbin Gao*, Shasha Zhang, Wenbo Zhu, Liang Wang, Rui Chen, Wenkang Zhang, Juncheng Wang, Feifei Yang; Jing Li, Lei Shen, Taolei Sun*, Mixed-solvent precipitation: a facile approach for nanoparticle self-assembled monolayers, Appl. Surf. Sci., 2019, 465, 526-531.
37. 刘康, 高冠斌*, 孙涛垒*, β-HgS 量子点的制备、性质及应用[J], 化学进展, 2017, 29, 776-784.
38. 胡雪娇, 高冠斌*, 张明曦*, 金纳米棒——从可控制备与修饰到纳米生物学与生物医学应用[J]，物理化学学报, 2017, 33, 1324-1337.
39. Guanbin Gao, Mingxi Zhang, Dejun Gong, Rui Chen, Xuejiao Hu and Taolei Sun*. The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation. Nanoscale, 2017, 9, 4107-4113.
40. Xuesong Lv, Zhixiong Huang*, Mingxian Shi*, Yun Fan, Guanbin Gao*, Composition Distribution, Damping and Thermal Properties of the Thickness-Continuous Gradient Epoxy/Polyurethane Interpenetrating Polymer Networks, Appl. Sci. -Basel, 2017, 7, 135.
41. 高冠斌，龚德君，张明曦*，孙涛垒*，手性金纳米团簇：一种新型近红外荧光探针，化学学报，2016，74，363-374.
42. Xuesong Lv*, Zhixiong Huang*, Minxian Shi, Yun Fan, Guanbin Gao*, Self-gradient mechanism, morphology and damping analysis of a thickness continuous gradient epoxy-polyurethane interpenetrating polymer network, RSC Adv., 2016, 6, 111688-111701.
43. Guanbin Gao, Mingxi Zhang, Pei Lu, Guanlun Guo, Dong Wang and Taolei Sun*. Chirality-assisted ring-like aggregation of Aβ(1-40) at liquid-solid interfaces: a stereoselective two-step assembly process. Angew. Chem. Int. Ed., 2015, 54, 2245-2250.
七、专利
(1) 高冠斌;张斌;孙涛垒. 一种尺寸可调的硫化亚铜量子点的水相合成方法. 专利号：ZL202210877107.9, 授权日期：2023.04.07
(2) 高冠斌;曹柏胜;孙涛垒. 谷胱甘肽修饰的硫化亚铁纳米粒子的制备方法及其在葡萄糖检测中的应用. 专利号：ZL202210877106.4, 授权日期：2023.04.25
(3) 高冠斌;谷振华;孙涛垒. 硼氢化钠原位还原制备石墨烯负载金团簇纳米复合材料的方法及应用. 专利号：ZL202210690903.1, 授权日期：2023.04.25
(4) 孙涛垒;高冠斌;余梦. 配体修饰的硫化锌纳米粒子、制备方法及其在治疗中的应用. 专利号：ZL202110310944.9, 授权日期：2023.07.14
(5) 高冠斌;邓昱周;孙涛垒. 一种基于溶剂辅助两相合成策略改良金团簇的制备方法.专利号：ZL202211235293.2, 授权日期：2023.10.22
(6) 高冠斌;邓浩;孙涛垒. 一种金银核壳纳米双锥-二氧化铈复合材料的制备方法. CN202210955619.2, 授权日期：2024.03.26
(7) 高冠斌;余良翀;万权;孙涛垒;杨进. 一种戊烯酸-异丙基丙烯酰胺共聚物修饰超小金纳米材料及制备方法, CN202211286226.3, 授权日期：2024.05.28
八、奖励与荣誉
1. 2024/10 入选国家级高层次青年人才
2. 2023/11 入选湖北省青年拔尖人才
3. 2019/11 入选中国科协优秀中外青年交流计划
4. 2023/09 入选武汉理工大学青年拔尖人才
5. 2023/03 获武汉理工大学自然科学一等奖（排 2）
6. 2022/09 获武汉理工大学“课程思政优秀教师”荣誉称号
7. 2021/09 入选 2021 年度武汉理工大学“青年教师十大科技进展”
8. 2021/09 获武汉理工大学教师教学创新大赛一等奖
9. 2020/12 获锐捷智慧教育支持奖
